Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target

The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins. However, if the unfolded protein response fails to restore endoplasmic reticulum homeostasis, it can trigger pro-inflammat...

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Bibliographic Details

Published in:	Neural Regeneration Research
Main Authors:	Hongbing Zhang, Yalin Mu, Hongsong Li, Xiaogang Li
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2026-04-01
Subjects:	age-related macular degeneration autophagy diabetic retinopathy endoplasmic reticulum stress inflammasome inflammation mitochondrial diseases mutation nuclear receptors photoreceptor cells proteostasis proteotoxic stress retinal diseases retinitis pigmentosa
Online Access:	https://journals.lww.com/10.4103/NRR.NRR-D-24-01124