Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation

Mammalian transducin-like enhancer of split family proteins (TLEs) are homologous to Drosophila Groucho (Gro) and are essential transcriptional repressors. Seven TLE family members, TLE1-7, have been identified to date. These proteins do not bind DNA directly; instead, they bind a set of transcripti...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Guiping Yu, Yiqi Chen, Yuwen Hu, Yan Zhou, Xiaoling Ding, Xiaorong Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	TLE family proteins transcriptional repressors tumorigenesis inflammation cancer therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.1010639/full