PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to glycolysis, which plays an important role in tumor...

Full description

Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2024-07-01
Subjects:	Breast cancer HIF-1α PDK1 Protein phosphorylation Transcriptional activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304223003112