The intricate mechanism of PLS3 in bone homeostasis and disease

Since our discovery in 2013 that genetic defects in PLS3 lead to bone fragility, the mechanistic details of this process have remained obscure. It has been established that PLS3 variants cause syndromic and nonsyndromic osteoporosis as well as osteoarthritis. PLS3 codes for an actin-bundling protein...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Wenchao Zhong, Janak L. Pathak, Yueting Liang, Lidiia Zhytnik, Gerard Pals, Elisabeth M. W. Eekhoff, Nathalie Bravenboer, Dimitra Micha
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	PLS3 bone cells mechanotransduction calcium regulation osteogenesis bone diseases
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1168306/full