NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns

Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage, and in response they initiate a form of lytic regulated cell death called pyroptosis. Inflammasomes signal via homotypic protein-protein interactions where CARD or PYD domains are crucial for recruiting downstrea...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Bo Wei, Zachary P. Billman, Kengo Nozaki, Helen S. Goodridge, Edward A. Miao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	inflammasome NLRP3 NLRP6 NLRP12 NLRP12 autoinflammatory disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1418290/full