circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway

Abstract Macrophages act as the first immune defense line of the host against Mycobacterium tuberculosis (Mtb). A previous study showed that circRNA_SLC8A1 was significantly upregulated in Mtb-infected macrophages, but its regulatory mechanism in anti-tuberculosis infection is unclear. Therefore, th...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Zhenyun Li, Yuan Gao, Bianfang Zhang, Wei Dong, Yuling Xi, Yan Li, Junwei Cui
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Subjects:	Mycobacterium tuberculosis Macrophages circRNA_SLC8A1 miR‐20b‐5p SQSTM1/p62 The NF-κB signaling pathway
Online Access:	https://doi.org/10.1038/s41598-024-55493-9