Neuroanatomical alterations and synaptic plasticity impairment in the perirhinal cortex of the Ts65Dn mouse model of Down syndrome

Down syndrome (DS), a genetic condition due to triplication of Chromosome 21, is characterized by numerous neurodevelopmental alterations and intellectual disability. Individuals with DS and DS mouse models are impaired in several memory domains, including hippocampus-dependent declarative (spatial,...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Vincenzo Roncacé, Costanza Burattini, Fiorenza Stagni, Sandra Guidi, Andrea Giacomini, Marco Emili, Giorgio Aicardi, Renata Bartesaghi
Format:	Article
Language:	English
Published:	Elsevier 2017-10-01
Subjects:	Down syndrome Memory impairment Ts65Dn model Perirhinal cortex Synaptic function GIRK2
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996117301432