HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

Abstract Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide association summary statistics and apply it to 372...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Daniel M. Jordan, Marie Verbanck, Ron Do
Format:	Article
Language:	English
Published:	BMC 2019-10-01
Subjects:	Pleiotropy Polygenicity Genetic architecture GWAS Statistical method R package
Online Access:	http://link.springer.com/article/10.1186/s13059-019-1844-7