HIF1α stabilization in hypoxia is not oxidant-initiated

Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second messenger peroxide. Here, we use a ratiometric, pero...

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Bibliographic Details
Published in:eLife
Main Authors: Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Subjects:
hypoxia
mitochondria
peroxide
HIF PHDs
oxygen
HIF1α stability
Online Access:https://elifesciences.org/articles/72873

Internet

https://elifesciences.org/articles/72873

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