The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

ABSTRACT In children, hyper‐IgM syndrome type 1 (HIGM1) is a type of severe antibody disorder, the pathogenesis of which remains unclear. The antibody diversity is partially determined by the alternative splicing (AS) in the germline, which is mainly regulated by RNA‐binding proteins, including Brea...

Full description

Bibliographic Details

Published in:	Exploration
Main Authors:	Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen
Format:	Article
Language:	English
Published:	Wiley 2025-06-01
Subjects:	alternative splicing Bcas2 class switch recombination CLIP‐seq hyper‐IgM syndrome type 1 RNA binding proteins
Online Access:	https://doi.org/10.1002/EXP.70015