FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin

Summary: KLF15 is a transcription factor that plays an important role in the activation of gluconeogenesis from amino acids as well as the suppression of lipogenesis from glucose. Here we identified the transcription start site of liver-specific KLF15 transcript and showed that FoxO1/3 transcription...

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Bibliographic Details

Published in:	iScience
Main Authors:	Yoshinori Takeuchi, Naoya Yahagi, Yuichi Aita, Zahra Mehrazad-Saber, Man Hei Ho, Yiren Huyan, Yuki Murayama, Akito Shikama, Yukari Masuda, Yoshihiko Izumida, Takafumi Miyamoto, Takashi Matsuzaka, Yasushi Kawakami, Hitoshi Shimano
Format:	Article
Language:	English
Published:	Elsevier 2021-12-01
Subjects:	Molecular biology Molecular network Diabetology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221014176