Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

Abstract In patients with ischaemic stroke, retrograde perfusion of the penumbra by leptomeningeal collateral vessels (LMCs) strongly predicts clinical outcome, suggesting that enhancing LMC flow can offer a novel therapeutic approach. Using in vivo measurements and computational modelling it is sho...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Advanced Science
المؤلفون الرئيسيون:	Magdalena Litman, Sara Azarpeykan, Rebecca J Hood, Kristy Martin, Debbie Pepperall, Daniel Omileke, Fern Williams, Oktay Uzun, Deen Bhatta, Yuen K Yong, Alex Chan, Nicholas Hough, Sarah Johnson, Pablo Garcia Bermejo, Ferdinand Miteff, Carlos Garcia Esperon, Yvonne Couch, Alastair M Buchan, Neil J Spratt, Netanel Korin, Donald E Ingber, Daniel J Beard
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Wiley 2025-10-01
الموضوعات:	collateral therapeutics collaterals ischaemic stroke nanotherapeutics shear stress
الوصول للمادة أونلاين:	https://doi.org/10.1002/advs.202506276