The ADAM17 inhibitor ZLDI-8 sensitized hepatocellular carcinoma cells to sorafenib through Notch1-integrin β-talk

ZLDI-8 is an A disintegrin and metalloproteinase domain 17 (ADAM17) inhibitor that suppresses the shedding of Notch1 to the Notch1 intracellular domain (NICD). In previous studies, we found that ZLDI-8 was able to sensitize HCC to sorafenib, but the mechanism of action remains unclear. The sensitizi...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Pharmacological Research
المؤلفون الرئيسيون:	Chang Xu, Xudong Gao, Tianshu Ren, Hefeng Geng, Kaisi Yang, Yaoguang Huang, Weige Zhang, Shanbo Hou, Aigang Song, Yingshi Zhang, Qingchun Zhao
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2024-05-01
الموضوعات:	Notch1 Integrinβ ILK Sorafenib Crosstalk
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S1043661824000860