Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A

Abstract Background Large number of microRNAs (miRNAs) have been found to be dysregulated in β-thalassemia, but their roles in β-thalassemia are poorly reported. This study aims to investigate the clinical significance of miR-17-3p in β-thalassemia, and to elucidate its regulatory effect on erythrop...

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Bibliographic Details

Published in:	Orphanet Journal of Rare Diseases
Main Authors:	Siwen Zhang, Meihuan Chen, Wantong Zhao, Junhao Zheng, Yanhong Zhang, Aixiang Lv, Jingmin Li, Hua Cao, Liangpu Xu, Hailong Huang
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	β-thalassemia miR-17-3p BCL11A HbF Erythropoiesis
Online Access:	https://doi.org/10.1186/s13023-025-03806-0