Drosophila VCP/p97 Mediates Dynein-Dependent Retrograde Mitochondrial Motility in Axons

Valosin-containing protein (VCP), also called p97, is an evolutionarily conserved and ubiquitously expressed ATPase with diverse cellular functions. Dominant mutations in VCP are found in a late-onset multisystem degenerative proteinopathy. The neurological manifestations of the disorder include fro...

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Bibliographic Details
Published in:Frontiers in Cell and Developmental Biology
Main Authors: Ashley E. Gonzalez, Xinnan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
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Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00256/full