β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction

Introductionβ-Elemene, derived from Curcuma zedoaria (Wenyujin), is clinically recognized for inducing apoptosis, inhibiting cell cycle progression, and reversing chemotherapy resistance in various cancers. However, its effects on radioresistant gastric cancer (GC) remain unclear.MethodsIn this stud...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Jiancheng He, Ming Li, Jiapeng Bao, Yifeng Peng, Wanjiang Xue, Junjie Chen, Jun Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	gastric cancer β-elemene ferroptosis ubiquitination GPx4 OUTB1
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1469180/full