Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

The effect of the combination of 10-Hydroxycamptothecin (HCPT) and crizotinib (CRI) on EGFR- and KRAS-mutant lung cancer cells was investigated and the conjugates of the two drugs were synthesised. HCPT combined with CRI synergistically inhibited the cell growth and proliferation of H1975, HCC827, a...

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Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Zhen Liu, Ye Xu, Lvqian Guo, Xinran Li, Junling Gao, Weiran Xie, Lianbo Zhao, Yuou Teng, Xuejiao Li, Peng Yu
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	10-Hydroxycamptothecin crizotinib EGFR NSCLC conjugate
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2022.2132487