IDO-Mediated Immune and Metabolic Dysregulation in Schwann Cells Exposed to <i>Mycobacterium leprae</i>

Leprosy is a chronic infectious disease that targets the peripheral nervous system, leading to peripheral neuropathy. <i>Mycobacterium leprae</i> primarily infects Schwann cells, adipocytes, and macrophages, altering their metabolism and gene expression. This study investigates the metab...

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Bibliographic Details

Published in:	Cells
Main Authors:	Atta Ur Rahman, Raíssa Couto Santana, Mylena Masseno de Pinho Pereira, Claudia Luciana dos Santos Moura, Débora Santos da Silva, Otto Castro Araujo, Thyago Leal-Calvo, Isabela Espasandin, Tatiana Pereira da Silva, Euzenir Nunes Sarno, Bruno Jorge de Andrade Silva, Rubem Sadok Figueiredo Menna-Barreto, Márcia Maria Jardim, Cristiana Santos de Macedo, Flávio Alves Lara, Roberta Olmo Pinheiro
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	<i>Mycobacterium leprae</i> Schwann cells Indoleamine 2,3 Dioxygenase (IDO) kynurenine pathway
Online Access:	https://www.mdpi.com/2073-4409/14/19/1550