Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. Apo...

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發表在:	Frontiers in Neuroscience
Main Authors:	Sabine C. Konings, Laura Torres-Garcia, Isak Martinsson, Gunnar K. Gouras
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2021-09-01
主題:	Apolipoprotein E Alzheimer’s disease synapse neuron astrocyte amyloid
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fnins.2021.734001/full