Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution

Cationic porphyrins exhibit an amazing variety of binding modes and inhibition mechanisms of 20S proteasome. Depending on the spatial distribution of their electrostatic charges, they can occupy different sites on α rings of 20S proteasome by exploiting the structural code responsible for the intera...

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發表在:	Biomolecules
Main Authors:	Marco Persico, Anna Maria Santoro, Alessandro D’Urso, Danilo Milardi, Roberto Purrello, Alessandra Cunsolo, Marina Gobbo, Roberto Fattorusso, Donatella Diana, Manuela Stefanelli, Grazia R. Tundo, Diego Sbardella, Massimo Coletta, Caterina Fattorusso
格式:	Article
語言:	英语
出版:	MDPI AG 2022-05-01
主題:	h20S proteasome modulators cationic porphyrins NMR kinetic studies molecular docking
在線閱讀:	https://www.mdpi.com/2218-273X/12/6/741