Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia

BackgroundAllogeneic hematopoietic stem cell transplant remains the most effective strategy for patients with high-risk acute myeloid leukemia (AML). Leukemia-specific neoantigens presented by the major histocompatibility complexes (MHCs) are recognized by the T cell receptors (TCR) triggering the g...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Mateusz Pospiech, Mukund Tamizharasan, Yu-Chun Wei, Advaith Maya Sanjeev Kumar, Mimi Lou, Joshua Milstein, Houda Alachkar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	acute myeloid leukemia T cell receptor (TCR) WT1 RNA sequencing (RNA-Seq) TCGA
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1236514/full