Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages.

Clinical data show that disease adversely affects tissue elasticity or stiffness. While macrophage activity plays a critical role in driving disease pathology, there are limited data available on the effects of tissue stiffness on macrophage activity. In this study, the effects of substrate stiffnes...

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Bibliographic Details
Published in:PLoS ONE
Main Authors: Michelle L Previtera, Amitabha Sengupta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145813&type=printable