Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis

Abstract The proinflammatory cytokines and arachidonic acid (AA)-derived eicosanoids play a key role in cartilage degeneration in osteoarthritis (OA). The lysophosphatidylcholine acyltransferase 3 (LPCAT3) preferentially incorporates AA into the membranes. Our recent studies showed that MALT1 [mucos...

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Bibliographic Details
Published in:Cell Communication and Signaling
Main Authors: Vijay Kondreddy, Rajkumar Banerjee, B. L. A. Prabhavathi Devi, Kathirvel Muralidharan, Selvakumar Piramanayagam
Format: Article
Language:English
Published: BMC 2024-03-01
Subjects:
LPCAT3
Lipid nanoparticles
MALT1
Cytokines
Eicosanoids
Osteoarthritis
Online Access:https://doi.org/10.1186/s12964-024-01547-4

Internet

https://doi.org/10.1186/s12964-024-01547-4

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