Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

The first S-adenosyl methionine (SAM) degrading enzyme (SAMase) was discovered in bacteriophage T3, as a counter-defense against the bacterial restriction-modification system, and annotated as a SAM hydrolase forming 5’-methyl-thioadenosine (MTA) and L-homoserine. From environmental phages, we recen...

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Bibliographic Details

Published in:	eLife
Main Authors:	Xiaohu Guo, Annika Söderholm, Sandesh Kanchugal P, Geir V Isaksen, Omar Warsi, Ulrich Eckhard, Silvia Trigüis, Adolf Gogoll, Jon Jerlström-Hultqvist, Johan Åqvist, Dan I Andersson, Maria Selmer
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-02-01
Subjects:	bacteriophage S-adenosyl methionine lyase
Online Access:	https://elifesciences.org/articles/61818