Zolpidem Activation of Alpha 1-Containing GABAA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against damage, e.g., by using drugs that act as positive allo...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Elena Neumann, Uwe Rudolph, Daniel E. Knutson, Guanguan Li, James M. Cook, Harald Hentschke, Bernd Antkowiak, Berthold Drexler
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-01-01
Subjects:	zolpidem benzodiazepines GABAA receptor subtypes neocortex electrophysiology GABAA receptor subtype specific drugs
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2018.01523/full