Semantic search using protein large language models detects class II microcins in bacterial genomes

ABSTRACT Class II microcins are antimicrobial peptides that have shown some potential as novel antibiotics. However, to date, only 10 class II microcins have been described, and the discovery of novel microcins has been hampered by their short length and high sequence divergence. Here, we ask if we...

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Bibliographic Details

Published in:	mSystems
Main Authors:	Anastasiya V. Kulikova, Jennifer K. Parker, Bryan W. Davies, Claus O. Wilke
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-10-01
Subjects:	class II microcin protein large language model embedding
Online Access:	https://journals.asm.org/doi/10.1128/msystems.01044-24