Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency. Incorporating 4-1BB costimulation in CARs may enable T cells to resist this functional exhaustion; however, the potential ramifications of tonic 4-...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Diogo Gomes-Silva, Malini Mukherjee, Madhuwanti Srinivasan, Giedre Krenciute, Olga Dakhova, Yueting Zheng, Joaquim M.S. Cabral, Cliona M. Rooney, Jordan S. Orange, Malcolm K. Brenner, Maksim Mamonkin
Format:	Article
Language:	English
Published:	Elsevier 2017-10-01
Subjects:	chimeric antigen receptor costimulation 4-1BB T cells adoptive T cell therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717312767