Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk

Abstract Background Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapies. Circulating bile acids with immunosuppressive effects were recently...

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Bibliographic Details

Published in:	Critical Care
Main Authors:	Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers, Michael Bauer
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Cholestasis TGR5 GPBAR1 Lipopolysaccharide LPS Monocytes
Online Access:	https://doi.org/10.1186/s13054-023-04620-5