Approaches to manipulating microRNAs in neurogenesis

Neurogenesis in the nervous system is regulated by both protein coding genes and noncoding RNA molecules. microRNAs (miRNAs) are endogenous small noncoding RNAs and usually negatively regulate gene expression by binding to the 3’ untranslated region (3’UTR) of target messenger RNAs (mRNAs). miRNAs...

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Bibliographic Details
Published in:Frontiers in Neuroscience
Main Authors: Haijun eZhang, Benjamin eShykind, Tao eSun
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Subjects:
MicroRNAs
Neurogenesis
loss-of-function
gain-of-function
miRNA inhibitor
miRNA sponge
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00196/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00196/full

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