First Total Synthesis and Biological Screening of a Proline-Rich Cyclopeptide from a Caribbean Marine Sponge

A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester with the tripeptide Boc-l-leucyl-l-isoleucyl-l...

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Bibliographic Details

Published in:	Marine Drugs
Main Authors:	Rajiv Dahiya, Sunil Singh, Ajay Sharma, Suresh V. Chennupati, Sandeep Maharaj
Format:	Article
Language:	English
Published:	MDPI AG 2016-12-01
Subjects:	stylissamide G cycloheptapeptide Stylissa caribica peptide synthesis macrocyclization pharmacological activity marine sponge
Online Access:	http://www.mdpi.com/1660-3397/14/12/228