TSG6 affects anti cancer drug resistance and angiogenesis in 3D spheroid model of canine mammary gland tumor cells

Abstract TSG6 (Tumor necrosis factor stimulated gene-6) plays a critical role in modulating the tumor microenvironment by regulating inflammation, immune responses, and extracellular matrix remodeling. Hypoxia affects tumor growth, angiogenesis, and anti-cancer drug resistance in the tumor microenvi...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ga-Hyun Lim, Ju-Hyun An, Jeong-Hwa Lee, Kyoung-Won Seo, Hwa-Young Youn
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	Angiogenesis Anti-cancer drug resistance Canine mammary gland tumor TSG6 Tumor microenvironment Spheroid
Online Access:	https://doi.org/10.1038/s41598-025-12950-3