Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/- mouse studies having informed our understanding of GZMA’s physiological function. We show herein that Gzma-/- mice have a mixed C57BL/6J and C57BL/6N genetic background and retain the full-length nicotinamide nucl...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Daniel J Rawle, Thuy T Le, Troy Dumenil, Cameron Bishop, Kexin Yan, Eri Nakayama, Phillip I Bird, Andreas Suhrbier
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-02-01
Subjects:	granzyme A nicotinamide nucleotide transhydrogenase chikungunya inflammation C57BL/6J C57BL/6N
Online Access:	https://elifesciences.org/articles/70207