Transfection of hypoxia-inducible factor-1α mRNA upregulates the expression of genes encoding angiogenic growth factors

Abstract Hypoxia-Inducible Factor-1α (HIF-1α) has presented a new direction for ischemic preconditioning of surgical flaps to promote their survival. In a previous study, we demonstrated the effectiveness of HIF-1a DNA plasmids in this application. In this study, to avoid complications associated wi...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jakub Wlodarczyk, Albert Leng, Sanaz Nourmohammadi Abadchi, Niloufar Shababi, Farzad Mokhtari-Esbuie, Shayan Gheshlaghi, Mohsen Rouhani Ravari, Emma K. Pippenger, Ali Afrasiabi, Jinny Ha, John M. Abraham, John W. Harmon
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Subjects:	HIF-1a mRNA transfection Pedicle flap Angiogenic genes
Online Access:	https://doi.org/10.1038/s41598-024-54941-w