A novel feeder cell based on 4-1BBL and membrane-bound IL-21/IL-15 induce highly expansion and anti-tumor effect of natural killer cells

Abstract Background Natural killer (NK) cell immunotherapy is a promising approach for cancer treatment. However, its extensive clinical application was limited to the large-scale clinical-grade expansion of NK cells. In this study, we expanded NK cells from healthy donor’s peripheral blood mononucl...

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Bibliographic Details

Published in:	BMC Biotechnology
Main Authors:	Sha Gong, Nan Mei, Jun Wang, Junsheng Zhu, Lu Wang, Xiaohong Lu, Pengcheng He, Weiwei Chen, Lei Xi, Yingying Bao, David N. Wald, Xiaohu Fan, Huaiyu Wang
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	NK cells expansion Feeder cells mbIL-21 mbIL-15
Online Access:	https://doi.org/10.1186/s12896-025-01024-x