The antibacterial activity of a novel highly thermostable endolysin, LysKP213, against Gram-negative pathogens is enhanced when combined with outer membrane permeabilizing agents

Phages and phage-encoded lytic enzymes are promising antimicrobial agents. In this study, we report the isolation and identification of bacteriophage KP2025 from Klebsiella pneumoniae. Bioinformatics analysis of KP2025 revealed a putative endolysin, LysKP213, containing a T4-like_lys domain. Purifie...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Dingjian Chu, Jing Lan, Lu Liang, Kaide Xia, Linlin Li, Lan Yang, Hongmei Liu, Tingting Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	phage phage endolysin Gram-negative bacteria polymyxin B cecropin A synergy
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1454618/full