Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

New derivatives were synthesised by reaction of amino-containing aromatic sulphonamides with mono-, bi-, and tricyclic anhydrides. These sulphonamides were investigated as human carbonic anhydrases (hCAs, EC 4.2.1.1) I, II, IX, and XII inhibitors. hCA I was inhibited with inhibition constants (Kis)...

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發表在:	Pharmaceuticals
Main Authors:	Kalyan K. Sethi, KM Abha Mishra, Saurabh M. Verma, Daniela Vullo, Fabrizio Carta, Claudiu T. Supuran
格式:	Article
語言:	英语
出版:	MDPI AG 2021-07-01
主題:	human carbonic anhydrase inhibitors benzenesulphonamide anhydride docking SAR
在線閱讀:	https://www.mdpi.com/1424-8247/14/7/693