A Complementarity‐Based Approach to De Novo Binder Design

Abstract De novo design of binders capable of targeting arbitrarily selected epitopes remains a substantial challenge. Here, a generalizable computational strategy is presented to design site‐specific protein binders, obviating steps of extensive empirical optimization or in vitro screening. The doc...

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Bibliographic Details
Published in:Advanced Science
Main Authors: Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán‐Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D. Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N. Lupas, Julia Skokowa, Mohammad ElGamacy
Format: Article
Language:English
Published: Wiley 2025-09-01
Subjects:
complementarity evaluation
de novo binder design
IL‐7R binders
protein‐protein docking
VEGF inhibitors
Online Access:https://doi.org/10.1002/advs.202502015

Internet

https://doi.org/10.1002/advs.202502015

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