Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment

Bone-targeted polymeric nanoparticles for alendronate delivery based on Poly (lactic-co-glycolic acid) conjugated chitosan (CS-PLGA) and alendronate conjugated PLGA (Alen-PLGA) are fabricated and their superior performances are evaluated. The nanoparticles exhibited sustained Alen release without ob...

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Bibliographic Details

Published in:	Polymer Testing
Main Authors:	Chunlan Jing, Shenmao Chen, Sehajdev Singh Bhatia, Bowen Li, Hongze Liang, Chaozong Liu, Zhenjiang Liang, Junying Liu, Haiyan Li, Ziyu Liu, Hui Tan, Lingling Zhao
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Subjects:	Osteoporosis Nanoparticles Bone-targeted Alendronate
Online Access:	http://www.sciencedirect.com/science/article/pii/S014294182200109X