VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300

Studies on Hippo pathway regulation of tumorigenesis largely center on YAP and TAZ, the transcriptional co-regulators of TEADs. Here, we present an oncogenic mechanism involving VGLL and TEAD fusions that is Hippo pathway-related but YAP/TAZ-independent. We characterize two recurrent fusions, VGLL2-...

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الحاوية / القاعدة:	eLife
المؤلفون الرئيسيون:	Susu Guo, Xiaodi Hu, Jennifer L Cotton, Lifang Ma, Qi Li, Jiangtao Cui, Yongjie Wang, Ritesh P Thakare, Zhipeng Tao, Y Tony Ip, Xu Wu, Jiayi Wang, Junhao Mao
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	eLife Sciences Publications Ltd 2025-05-01
الموضوعات:	VGLL2 TEAD HIPPO YAP NCOA2 EP300
الوصول للمادة أونلاين:	https://elifesciences.org/articles/98386