Human pancreatic tumour organoid‐derived factors enhance myogenic differentiation

Abstract Background Most patients with pancreatic cancer develop cachexia, which is characterized by progressive muscle loss. The mechanisms underlying muscle loss in cancer cachexia remain elusive. Pancreatic tumour organoids are 3D cell culture models that retain key characteristics of the parent...

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Bibliographic Details

Published in:	Journal of Cachexia, Sarcopenia and Muscle
Main Authors:	Rianne D.W. Vaes, David P.J. vanDijk, Elham Aïda Farshadi, Steven W.M. Olde Damink, Sander S. Rensen, Ramon C. Langen
Format:	Article
Language:	English
Published:	Wiley 2022-04-01
Subjects:	Cachexia Skeletal muscle atrophy Organoids E3 ubiquitin ligases Myogenesis
Online Access:	https://doi.org/10.1002/jcsm.12917