A missense mutation in human INSC causes peripheral neuropathy

Abstract PAR3/INSC/LGN form an evolutionarily conserved complex required for asymmetric cell division in the developing brain, but its post-developmental function and disease relevance in the peripheral nervous system (PNS) remains unknown. We mapped a new locus for axonal Charcot–Marie-Tooth diseas...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Jui-Yu Yeh, Hua-Chuan Chao, Cheng-Li Hong, Yu-Chien Hung, Fei-Yang Tzou, Cheng-Tsung Hsiao, Jeng-Lin Li, Wen-Jie Chen, Cheng-Ta Chou, Yu-Shuen Tsai, Yi-Chu Liao, Yu-Chun Lin, Suewei Lin, Shu-Yi Huang, Marina Kennerson, Yi-Chung Lee, Chih-Chiang Chan
Format:	Article
Language:	English
Published:	Springer Nature 2024-04-01
Subjects:	Charcot–Marie–Tooth Neuropathy Type 2 Inscuteable Microtubule-Stabilizing Agents Necrosis Proprioception
Online Access:	https://doi.org/10.1038/s44321-024-00062-w