Mitochondrial echoes in the bloodstream: decoding ccf-mtDNA for the early detection and prognosis of hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC), the most common primary liver cancer, remains a major global health burden due to its high recurrence, late diagnosis, and limited prognostic tools. While imaging and treatment modalities have advanced, there is an urgent need for reliable, noninvasive biomar...

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Bibliographic Details

Published in:	Cell & Bioscience
Main Authors:	Yu-De Chu, Wei-Ting Chen, Wey-Ran Lin, Ming-Wei Lai, Chau-Ting Yeh
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Hepatocellular carcinoma Circulating mitochondrial DNA Extracellular vesicle Diagnosis and prognosis
Online Access:	https://doi.org/10.1186/s13578-025-01456-0