PACAP38-induced migraine attacks are independent of CGRP signaling: a randomized controlled trial

Abstract Background Calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) are key pathogenic drivers of migraine. While CGRP has become the target of several mechanism-based therapies, less is known about PACAP38 signaling in migraine pathogenesis...

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Bibliographic Details

Published in:	The Journal of Headache and Pain
Main Authors:	Mohammad Al-Mahdi Al-Karagholi, Zixuan Alice Zhuang, Signe Beich, Håkan Ashina, Messoud Ashina
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Migraine Headache Pain Pathophysiology CGRP PACAP-38
Online Access:	https://doi.org/10.1186/s10194-025-02022-2