Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons

Abstract Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins. Translational readthrough of PTCs induced by pharmaceutical compounds is a promising way of restoring functional protein e...

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Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz
Format:	Article
Language:	English
Published:	BMC 2018-05-01
Subjects:	Translational readthrough Stop codon suppression Nonsense suppression Premature termination codon Genetic diseases
Online Access:	http://link.springer.com/article/10.1186/s10020-018-0024-7