Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affecting motor neurons. Motor neuron degeneration is accompanied and aggravated by oligodendroglial pathology and the presence of reactive astrocytes and microglia. We studied the role of the Notch signaling...

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書誌詳細

出版年:	Neurobiology of Disease
主要な著者:	Annelies Nonneman, Nathan Criem, Sebastian A. Lewandowski, Rik Nuyts, Dietmar R. Thal, Frank W. Pfrieger, John Ravits, Philip Van Damme, An Zwijsen, Ludo Van Den Bosch, Wim Robberecht
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2018-11-01
主題:	Amyotrophic lateral sclerosis Notch Jagged-1 Cis Trans Astrocyte
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0969996118302493