Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro

IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer activity of most cytokines, including IL-15, has been limited by low tolerability and rapid in vivo clearance. Efbalropendekin Alfa (XmAb24306) is...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hesham M. Shehata, Pranay Dogra, Sarah Gierke, Patrick Holder, Shomyseh Sanjabi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Subjects:	IL-15 immunotherapy NK cells cytotoxicity cytokine
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341804/full