MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated p...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Lin Shibo, Hoffmann Katrin, Xiao Zhi, Jin Nan, Galli Uwe, Mohr Elvira, Büchler Markus W, Schemmer Peter
Format:	Article
Language:	English
Published:	BMC 2013-01-01
Subjects:	Hepatocellular carcinoma MEK MRP1 MRP3 Multidrug resistance
Online Access:	http://www.cancerci.com/content/13/1/3