GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage

Abstract Growth differentiation factor 15 (GDF15) as a stress response cytokine is involved in the development and progression of several diseases associated with metabolic disorders. However, the regulatory role and the underlying mechanisms of GDF15 in sepsis remain poorly defined. Our study analy...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Shasha Lu, Ranran Li, Yunxin Deng, Ju Bai, Bangqi Ji, Yufeng Chu, Yan Xu, Hongping Qu, Xiaosun Guo, Pibao Li, Mei Meng
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Growth differentiation factor 15(GDF15) Glycolysis Inflammation sepsis Alveolar macrophage
Online Access:	https://doi.org/10.1186/s12931-024-02824-z