Hypoxia reverses the early anti-inflammatory microglial response to the β-amyloid peptide: mitochondrial involvement and beneficial roles of melatonin and naringenin

Abstract Background Early Alzheimer’s disease (AD) is characterized by anti-inflammatory microglial responses to the beta amyloid peptide (Aβ), which later switch to pro-inflammatory. Such transition is relevant to disease progression and can be affected by concurrent insults, such as hypoxia (HY)....

Full description

Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Cristiana Lucia Rita Lipari, Aurora Patti, Stefano Conti-Nibali, Angela Anna Messina, Andrea Magrì, Maria Angela Sortino, Sara Merlo
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Microglial HMC3 cells Alzheimer’s disease Hypoxia SIRT1 Neuroinflammation Natural substances
Online Access:	https://doi.org/10.1186/s12967-025-07044-7