Secretion of transthyretin: molecular mechanisms dependent on the endoplasmic reticulum

Hereditary transthyretin amyloidosis (ATTRv) results from genetic mutations that destabilize transthyretin (TTR), leading to the formation of extracellular aggregates and amyloid fibrils. A common pathological feature of ATTRv is the capacity of TTR variants to evade endoplasmic reticulum quality co...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Jia Meng, Shan-jun Cai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	endoplasmic reticulum endoplasmic reticulum quality control unfolded protein response transthyretin vitreous amyloidosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1623185/full